Solubilization and Humanization of Paraoxonase-1
نویسندگان
چکیده
منابع مشابه
Solubilization and Humanization of Paraoxonase-1
Paraoxonase-1 (PON1) is a serum protein, the activity of which is related to susceptibility to cardiovascular disease and intoxication by organophosphorus (OP) compounds. It may also be involved in innate immunity, and it is a possible lead molecule in the development of a catalytic bioscavenger of OP pesticides and nerve agents. Human PON1 expressed in E. coli is mostly found in the insoluble ...
متن کاملparaoxonase 1 phenotype and paraoxonase activity in asthmatic patients.
oxidative stress is involved in the pathogenesis of asthma. paraoxonase 1 (pon1) and arylesterase are esterase enzymes displaying antioxidant characteristics. pon1 activity varies widely among individuals and ethnic groups, partly related to polymorphisms. the aim of this study was to determine the activities of pon1 and arylesterase including the phenotype distribution of pon1 in asthmatic pat...
متن کاملParaoxonase 1 phenotype and paraoxonase activity in asthmatic patients.
Oxidative stress is involved in the pathogenesis of asthma. Paraoxonase 1 (PON1) and arylesterase are esterase enzymes displaying antioxidant characteristics. PON1 activity varies widely among individuals and ethnic groups, partly related to polymorphisms. The aim of this study was to determine the activities of PON1 and arylesterase including the phenotype distribution of PON1 in asthmatic pat...
متن کاملEffects of static and electromagnetic fields on human serum paraoxonase-1 activity in vitro
Introduction: In recent years the relationship between electromagnetic fields and coronary artery disease is attracted a considerable attention. Low density lipoprotein (LDL) oxidation is the initial step in the development of atherosclerosis. Paraoxonase1 (PON1) protects LDL and High density lipoprotein (HDL) against oxidative processes, thus preventing the formation of atherogenic (oxidized-L...
متن کامل[Association between paraoxonase-1 and paraoxonase-2 polymorphisms and the risk of acute myocardial infarction].
INTRODUCTION AND OBJECTIVES Two particular polymorphisms, namely PON1-192 and PON2-311, in the genes encoding the antioxidant enzymes paraoxonase-1 (PON1) and paraoxonase-2 (PON2) have been associated with an increased risk of acute myocardial infarction (AMI). However, previous findings have been contradictory. The aim of this study was to investigate the association between the PON1-192 and P...
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ژورنال
عنوان ژورنال: Journal of Lipids
سال: 2012
ISSN: 2090-3030,2090-3049
DOI: 10.1155/2012/610937